CHEM 4331: Biochemistry

Dr. Nick Flynn

Instructor information

Dr. Nick Flynn

Assistant Professor, Biochemistry

CAV 204 B

Phone: 325-942-2181 (ext 250)

Fax: 325-942-2184

Email: Instructor



Lehninger, Principles of Biochemistry

3rd Edition

David L. Nelson, Michael M. Cox

Textbook website. This website is an excellent resource for students and I strongly suggest that you visit it. Features of the website include the following:


Flashcards to help you remember key terms and concepts from each chapter

Additional Reading exercises 

3D Structure Tutorials

Protein Database






Class lecture notes

Here are the course lectures notes for the first 12 chapters in Lehninger. We are going to try to get to Chapter 13, but that is going to depend upon the progress of the class. These notes are provided to help you follow the lecture; they are incomplete and require you to attend class if you want to be able to make any sense out of them. Also, there are certain parts of the lecture notes that we will not cover in class for various reasons. Some of these files are rather large.


Chapter One

Chapter Two

Chapter Three

Chapter Four

Chapter Five

Chapter Six

Chapter Seven

Chapter Eight

Chapter Nine

Chapter Ten

Chapter Eleven

Chapter Twelve


Class media files

These media files are provided to assist with the instruction of CHEM 4331. Many of them are used during lecture.


Chapter One


Chapter Two

Protein targeting

Carbamoyl Phosphate Synthase One Mechanism (Web-based)

Chapter Four


Chapter Five

Protein purification

Gel Electrophoresis

Chapter Six

X-Ray Crystallography

Chapter Seven

Hemoglobin structure

Myoglobin structure

Concerted model of allostery

Sequential model of allostery

Chapter Eight

Enzyme action

Enzyme catalysis and transition state

Mechanism of chymotrypsin a

Mechanism of chymotrypsin b

Lineweaver-Burke plots

Mechanism of lysozyme

Chymotrypsin mechanism (Web-based)

Lysozyme mechanism (Web-based)

Carboxypeptidase A mechanism (Web-based)

Chapter Ten

DNA Structure

DNA sequencing

Chapter Twelve

Sodium-Potassium ATPase pump

Hydropathy index of proteins


Some interesting biochemistry links

(No specific approval, acceptance or review of any material is implied)