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Angelo State University
Department of Chemistry and Biochemistry

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Dr. Edith Marie Osborne

  • Edith Osborne
    Edith Osborne
    Photo by Danny Meyer

Department of Chemistry and Biochemistry

Associate Professor
  • Postdoctoral Fellowship, New England Biolabs
  • Ph.D., Biochemistry, Texas A&M University
  • B.S., Chemistry, Southwestern Oklahoma State University

General Chemistry I&II - CHEM 1311/1111 & 1312/1112

Biochemistry - CHEM 4331

Intermediary Metabolism - CHEM 4332

Biochemistry Laboratory - 4233

My research group focuses on solving biochemical problems, including incorporation of nonstandard amino acids into proteins and using phage display to explore interactions between proteins. One project aims to identify affibody proteins that will bind to proteins found in a variety of snake venoms, which might lead to additional tools for studying venom proteins. Affibodies are a type of small protein that can be designed to bind with high affinity to a researcher’s protein of choice. In our research, a library of affibody molecules displayed on M13 bacteriophage is being used to probe affibody/snake venom interactions. Bacteriophage, viruses that infect bacteria, are composed of a single-stranded circular DNA genome which is surrounded by a protein coat which protects it and interacts with bacteria during infection. The amino terminus of the minor coat protein pIII extends into solution so that proteins or peptides can be fused to it without an interruption of the infection function of pIII. The displaying of proteins or peptides on phage surfaces (phage display) has been used in several different applications, including drug development and materials science. Our lab teaches students modern biochemical techniques, which helps prepare them for graduate research and industry positions.

  • “Characterization of a Native Hammerhead Ribozyme Derived from Schistosomes.” E. M. Osborne, J. E. Schaak, and V. J. DeRose. 2005 RNA 11:187-196.

  • “Translational Recoding.” E. M. Osborne and Christopher J. Noren. 2008 Wiley Encyclopedia of Chemical Biology. Ed. Tadhg P. Begley. New York: John Wiley & Sons, Inc.

  • “The identity of the nucleophile substitution may influence metal interactions with the cleavage site of the minimal hammerhead ribozyme.” E. M. Osborne, W. L. Ward, M. Z. Ruehle, and V. J. DeRose. 2009 Biochemistry 48:44:10654–10664.

  • “Expanding the Genetic Code of Escherichia coli with Phosphoserine. H-S Park, M. J. Hohn, T. Umehara, L-T Guo, E. M. Osborne, J. Benner, C. J. Noren, J. Rinehart, and D. Söll. 2011 Science 333: 1151-1154.

  • Angelo State University Undergraduate Research/Creative Endeavor Symposium, April 2018, San Angelo, TX. “Development and identification of affibody molecules that target crotalid snake venoms.” Clancy Collom, Christopher Garcia, Jung Ah Kim, Amber Sullivan, Madison Sudduth, Karen A. Noren, Christopher J. Noren, E. Osborne
  • Southwest Regional American Chemical Society Meeting, October 2017, Lubbock, TX. “Development and identification of affibody molecules that target crotalid snake venoms.” Clancy Collom, Christopher Garcia, Jung Ah Kim, Amber Sullivan, Madison Sudduth, Karen A. Noren, Christopher J. Noren, E. Osborne
  • Angelo State University Undergraduate Research/Creative Endeavor Symposium, April 2017, San Angelo, TX. “Development and identification of affibody molecules that target crotalid snake venoms.” Amber Sullivan, Madison Sudduth, Karen Noren, Christopher J. Noren, and Edith M. Osborne.
  • National American Chemical Society Meeting, April 2017, San Francisco, CA. “Development and identification of affibody molecules that target crotalid snake venoms.” Amber Sullivan, Madison Sudduth, Karen Noren, Christopher J. Noren, and Edith M. Osborne.
  • National American Chemical Society Meeting, March 2014, Dallas, TX. “Hoffmeister Effects on the Structure and Fluorescence of Green Fluorescent Protein.” Joshua T. McGuire, Edith M. Osborne, and John J. Osterhout.
  • Angelo State University Undergraduate Research/Creative Endeavor Symposium, April 2014, San Angelo, TX. “Hoffmeister Effects on the Structure and Fluorescence of Green Fluorescent Protein.” Joshua T. McGuire, Edith M. Osborne, and John J. Osterhout.